Lipoprotein(a) Blood Test: Uncover Hidden Genetic Heart Disease Risk

Lipoprotein(a), or Lp(a), is a type of lipoprotein that transports cholesterol in the blood. Unlike other lipid markers, Lp(a) levels are largely genetically determined and are not significantly affected by diet or exercise. Elevated Lp(a) contributes to atherosclerotic plaque formation and can increase heart attack and stroke risk even in people with otherwise normal cholesterol. About 50% of heart attack patients have normal cholesterol, which is why researchers developed Lp(a) as an additional risk indicator. Wellth offers this test through accredited Swedish laboratories.

Why Test Lipoprotein (a)?

Testing Lp(a) is particularly important if you have a family history of cardiovascular disease, especially at a young age, or a personal history of heart attack or stroke with a normal or only slightly elevated lipid profile. Since Lp(a) is genetically determined, it only needs to be tested once in most cases. However, identifying elevated Lp(a) allows you and your healthcare provider to take targeted preventive action against other modifiable risk factors.

What Do High Lipoprotein (a) Levels Mean?

High Lp(a) increases the risk of cardiovascular disease by promoting atherosclerotic plaque development on blood vessel walls. It can occur in individuals with completely normal standard lipid profiles. Since Lp(a) is genetically determined, certain health conditions can further increase levels, and your doctor may investigate these. Symptoms associated with elevated Lp(a) include chest pain, shortness of breath, persistent fatigue, high blood pressure, heart palpitations, and yellowish cholesterol deposits under the skin (xanthomas).

What Do Low Lipoprotein (a) Levels Mean?

Low or undetectable Lp(a) is generally considered beneficial and is associated with a reduced risk of cardiovascular disease. Many people have no detectable Lp(a) in their blood. Low Lp(a) is not a cause for concern and does not produce symptoms.

Symptoms to Watch For

  • Often asymptomatic until cardiovascular events occur
  • Chest pain (angina)
  • Shortness of breath
  • Heart palpitations
  • Yellowish skin deposits (xanthomas)
  • Dizziness or lightheadedness

Who Should Get Tested?

  • Anyone with a family history of premature cardiovascular disease
  • People who have had a heart attack or stroke despite normal cholesterol
  • Individuals with familial hypercholesterolaemia
  • Those with a strong family history of elevated Lp(a)
  • Anyone wanting a comprehensive cardiovascular risk assessment

How to Prepare for Your Test

No advance preparation is needed for a standalone Lp(a) test. However, if it is ordered as part of a lipid profile, you may be advised to fast. Read the instructions carefully when ordering. Bring valid identification to the lab.

Order Your Blood Test

Test your Lipoprotein (a) levels with an accredited Swedish laboratory. Results within days, reviewed by Wellth.

Frequently Asked Questions

Is Lipoprotein(a) genetic?
Yes. Lp(a) levels are almost entirely determined by genetics. Unlike LDL cholesterol, they are not significantly affected by diet, exercise, or most medications. This is why testing once is usually sufficient.
Can I lower my Lipoprotein(a)?
Currently, there are no widely available treatments specifically targeting Lp(a), though clinical trials are ongoing. However, knowing your Lp(a) level allows you to aggressively manage other cardiovascular risk factors such as LDL, blood pressure, and lifestyle.
Why should I test Lp(a) if I cannot change it?
Knowing your Lp(a) level helps you and your doctor determine your total cardiovascular risk and make informed decisions about managing modifiable risk factors more aggressively if needed.
How often should I test Lipoprotein(a)?
Since Lp(a) is genetically determined, a single test is usually sufficient. Retesting may be warranted if your initial result was borderline or if your doctor suspects a secondary cause of elevation.
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Wellth

Our content is written and reviewed by Wellth, and fact-checked against peer-reviewed research and current Swedish clinical guidelines.

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Medical Disclaimer

The information on this page is provided for informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. Wellth provides health information and testing services but is not a substitute for clinical care. Always consult a qualified healthcare provider if you have questions about a medical condition. If you are experiencing severe or urgent symptoms, contact your doctor or call 1177 Vårdguiden. Blood test results should be interpreted by a qualified healthcare professional in the context of your complete medical history.