Hormones

High-Sensitivity Estradiol — When Precision Really Matters

Here's the problem with standard estrogen tests: they lose accuracy at very low levels. And for men — or anyone with naturally low estradiol — that's exactly where you need precision. This test uses liquid chromatography with mass spectrometry (LC-MS), the gold standard for measuring hormone levels below 80 pmol/L. It catches what regular tests miss.

Why Test Estrogen test, high sensitivity?

This test shines when you need to investigate puberty timing (early or late), track estrogen-producing tumours, evaluate amenorrhea, fine-tune hormones before IVF, or figure out gynecomastia in men. Men's estradiol lives in a range where standard tests just aren't reliable enough. This one is.

What Do High Estrogen test, high sensitivity Levels Mean?

Elevated high-sensitivity estradiol in men may point to estrogen-producing tumours, liver disease affecting estrogen breakdown, or medication side effects. In women, it could indicate ovarian hyperstimulation, tumours, or excessive aromatase activity.

What Do Low Estrogen test, high sensitivity Levels Mean?

Very low estradiol may suggest hypogonadism, ovarian failure, hypothalamic amenorrhea, or the effects of aromatase inhibitor therapy. In men, low estradiol can quietly erode bone density and shift metabolic balance.

Symptoms to Watch For

  • Gynecomastia in men
  • Delayed or absent puberty
  • Amenorrhea (absence of menstruation)
  • Bone density loss
  • Fertility problems
  • Changes in body composition

Who Should Get Tested?

  • Men with suspected estrogen imbalances
  • Children or adolescents with puberty concerns
  • Women with amenorrhea or very low estrogen
  • Patients being evaluated for estrogen-producing tumours
  • Those in IVF requiring precise hormone tracking

How to Prepare for Your Test

No special preparation needed. Bring valid ID. Note: this analysis is performed only by Karolinska University Laboratory, and sampling must take place at a Karolinska lab. If you take a supplement containing biotin (often sold for hair and nails), pause it for two days before the test, as high doses can distort the result.

Order Your Blood Test

Test your Estrogen test, high sensitivity levels with an accredited Swedish laboratory. Results within days, reviewed by Wellth.

High-Sensitivity Estradiol →

Frequently Asked Questions

How does this differ from a standard estrogen test?
It uses mass spectrometry instead of immunoassay. Much more accurate at measuring very low estradiol (below 80 pmol/L) — which is exactly the range that matters for men.
Why is this test important for men?
Men naturally have low estradiol. Standard tests can return unreliable numbers in that range. This test gives you a precise reading where it counts.
Where can I take this test?
This test is only available at Karolinska University Laboratory sampling stations in Sweden.
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Wellth Team

Wellth

Our content is written and reviewed by Wellth, and fact-checked against peer-reviewed research and current Swedish clinical guidelines.

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Medical Disclaimer

The information on this page is provided for informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. Wellth provides health information and testing services but is not a substitute for clinical care. Always consult a qualified healthcare provider if you have questions about a medical condition. If you are experiencing severe or urgent symptoms, contact your doctor or call 1177 Vårdguiden. Blood test results should be interpreted by a qualified healthcare professional in the context of your complete medical history.