Hormones
High-Sensitivity Estradiol
Hormones
Standard estrogen tests can't see the full picture when levels are very low. This one can. Built for men and clinical cases where every picomole counts.
VAT-exempt medical service
Here's the problem with standard estrogen tests: they lose accuracy at very low levels. And for men — or anyone with naturally low estradiol — that's exactly where you need precision. This test uses liquid chromatography with mass spectrometry (LC-MS), the gold standard for measuring hormone levels below 80 pmol/L. It catches what regular tests miss.
This test shines when you need to investigate puberty timing (early or late), track estrogen-producing tumours, evaluate amenorrhea, fine-tune hormones before IVF, or figure out gynecomastia in men. Men's estradiol lives in a range where standard tests just aren't reliable enough. This one is.
What a high value can mean
Elevated high-sensitivity estradiol in men may point to estrogen-producing tumours, liver disease affecting estrogen breakdown, or medication side effects. In women, it could indicate ovarian hyperstimulation, tumours, or excessive aromatase activity.
What a low value can mean
Very low estradiol may suggest hypogonadism, ovarian failure, hypothalamic amenorrhea, or the effects of aromatase inhibitor therapy. In men, low estradiol can quietly erode bone density and shift metabolic balance.
No special preparation needed. Bring valid ID. Note: this analysis is performed only by Karolinska University Laboratory, and sampling must take place at a Karolinska lab. If you take a supplement containing biotin (often sold for hair and nails), pause it for two days before the test, as high doses can distort the result.
Order your test
Choose your test and pay online. Your lab referral is created straight away.
Give your sample
Visit any of our partner sampling locations. No appointment needed at most of them.
The lab analyses it
Your sample is analysed at an accredited Swedish laboratory.
Get your results
Your values appear in your account with reference ranges and an explanation of each marker.
It uses mass spectrometry instead of immunoassay. Much more accurate at measuring very low estradiol (below 80 pmol/L) — which is exactly the range that matters for men.
Men naturally have low estradiol. Standard tests can return unreliable numbers in that range. This test gives you a precise reading where it counts.
This test is only available at Karolinska University Laboratory sampling stations in Sweden.