Allergy
Celiac Disease Test
Allergy
This blood test detects anti-tissue transglutaminase (anti-tTG) antibodies, the most sensitive and specific blood marker for coeliac disease.
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Tissue transglutaminase antibodies are found in the blood of people with coeliac disease, an autoimmune condition triggered by gluten (a protein in wheat, rye, and barley). The anti-tTG test is considered the most sensitive and specific blood test for coeliac disease and is measured alongside total IgA to ensure accurate results. A positive result often leads to further investigation, including intestinal biopsy, for definitive diagnosis.
This test is recommended if you have symptoms such as abdominal pain, diarrhoea, constipation, poor growth, weight loss, fatigue, or irritability. NICE guidelines recommend screening family members of coeliac patients, people with type 1 diabetes, autoimmune thyroid disease, IBS, unexplained iron, B12, and folate deficiencies, or persistent gastrointestinal symptoms.
What a high value can mean
A positive or borderline result suggests that you may have coeliac disease and should visit a doctor to discuss further steps. Positive tests may be followed by an intestinal biopsy for definitive diagnosis. The presence of these antibodies can precede clinical symptoms by years.
What a low value can mean
A negative result means no antibodies to the marker were detected. However, a negative test cannot fully rule out coeliac disease or non-coeliac gluten sensitivity, as only one marker is tested. Follow-up with additional markers may be recommended.
You must eat a moderate amount of gluten every day for 2-3 weeks before taking this test for accurate results. Do not start a gluten-free diet before testing. Bring your ID to the sampling location. Bring valid ID to your appointment.
Order your test
Choose your test and pay online. Your lab referral is created straight away.
Give your sample
Visit any of our partner sampling locations. No appointment needed at most of them.
The lab analyses it
Your sample is analysed at an accredited Swedish laboratory.
Get your results
Your values appear in your account with reference ranges and an explanation of each marker.
Yes. Anti-tissue transglutaminase is considered the most sensitive and specific single blood test for coeliac disease. It is best used alongside total IgA to rule out IgA deficiency, which can produce false negative results.
Yes, in rare cases. Some people with coeliac disease may test negative, especially if they have IgA deficiency or have already started a gluten-free diet. Additional markers like deamidated gliadin or Cyrex testing may be helpful.
A positive result should be discussed with a doctor, who may refer you for an intestinal biopsy to confirm the diagnosis. You should continue eating gluten until all tests are complete.
Yes. Consume gluten daily for at least 2-3 weeks before testing. A gluten-free diet before the test can produce false negative results.