Other
fS-Pepsinogen A
Other
Pepsinogen A is a stomach-produced precursor to the digestive enzyme pepsin. Testing it helps evaluate gastric mucosa health and stomach cancer risk.
VAT-exempt medical service
Pepsinogen A is a substance produced by cells in the stomach lining that is converted into pepsin, an important enzyme for protein digestion. A blood test measuring fasting pepsinogen A (fS-Pepsinogen A) assesses the condition of the gastric mucosa and the stomach's ability to produce acid. It is particularly useful for detecting signs of chronic gastritis, gastric ulcers, Helicobacter pylori infection, and even early indicators of stomach cancer risk.
This test is valuable if you experience upper abdominal discomfort, heartburn, or suspected gastritis. It is also relevant for people with a history of stomach ulcers, long-term H. pylori infection, or a family history of stomach cancer. Testing pepsinogen A provides a non-invasive way to evaluate stomach function and may support early detection of atrophic gastritis or gastric malignancy.
What a high value can mean
High pepsinogen A levels may be linked to increased stomach acid production and can be seen in rare conditions like Zollinger-Ellison syndrome, where tumours cause the stomach to produce excessive acid. Elevated levels should be interpreted alongside clinical symptoms and other gastric markers.
What a low value can mean
Low pepsinogen A levels suggest gastric mucosal atrophy — thinning of the stomach lining — commonly associated with chronic gastritis and potentially an increased risk of stomach cancer. Low values warrant further investigation, especially if combined with H. pylori infection or a family history of gastric cancer.
This test requires fasting — do not eat or drink anything except water before the blood draw. The analysis is performed twice per month with a typical result time of around 15 days. Bring valid ID to the sampling clinic.
Order your test
Choose your test and pay online. Your lab referral is created straight away.
Give your sample
Visit any of our partner sampling locations. No appointment needed at most of them.
The lab analyses it
Your sample is analysed at an accredited Swedish laboratory.
Get your results
Your values appear in your account with reference ranges and an explanation of each marker.
Atrophic gastritis is a condition where the stomach lining thins over time, reducing its ability to produce acid and digestive enzymes. It increases the risk of stomach cancer and is often associated with chronic H. pylori infection.
Pepsinogen A is not a standalone cancer diagnostic but can flag increased risk. Low levels may indicate atrophic gastritis, a known precursor to gastric cancer. Further investigation such as endoscopy is needed for diagnosis.
The laboratory analysis for pepsinogen A is typically performed twice per month, with results available in approximately 15 days.