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ACE Test (S-ACE) - Detect Lung Inflammation & Sarcoidosis

Angiotensin-converting enzyme (ACE) is an enzyme involved in regulating blood pressure and fluid balance. When certain inflammatory conditions cause the body to form granulomas — small clusters of immune cells — ACE levels in the blood often rise. The S-ACE test captures this change, making it a valuable tool for investigating diseases like sarcoidosis, which most commonly affects the lungs but can also involve the skin, eyes, and other organs.

Why Test ACE Test?

An ACE test is most often ordered when sarcoidosis is suspected, particularly if you have a persistent cough, fatigue, shortness of breath, swollen lymph nodes, or unusual findings on a chest X-ray. It can also aid in diagnosing or monitoring other granulomatous diseases such as tuberculosis, and in investigating unexplained high blood pressure or kidney problems. Tracking ACE levels over time helps assess disease activity and treatment response.

What Do High ACE Test Levels Mean?

Elevated ACE levels may indicate active sarcoidosis or another granulomatous condition. Less commonly, high values can stem from lung or kidney inflammation or other rare diseases. A high result is a diagnostic clue but not conclusive on its own — additional tests are typically required to confirm a diagnosis.

What Do Low ACE Test Levels Mean?

A normal or low ACE level is common and generally not a concern. Low values can occur if you are taking ACE inhibitors, a common medication for high blood pressure. In rare cases, reduced enzyme production related to kidney disease or other conditions may also lower ACE levels.

Symptoms to Watch For

  • Persistent cough
  • Unexplained fatigue
  • Shortness of breath
  • Swollen lymph nodes
  • Skin rashes or eye inflammation

Who Should Get Tested?

  • People with unexplained lung symptoms or abnormal chest imaging
  • Patients being monitored for sarcoidosis
  • Individuals with symptoms suggesting granulomatous inflammation
  • Those on ACE inhibitors who need to monitor treatment effects

How to Prepare for Your Test

Remember to bring valid ID to the sampling clinic.

Order Your Blood Test

Test your ACE Test levels with an accredited Swedish laboratory. Results within days, reviewed by Wellth.

Angiotensin-Converting Enzyme (ACE) →

Frequently Asked Questions

What is sarcoidosis?
Sarcoidosis is an inflammatory disease in which the body forms small clusters of immune cells called granulomas, most often in the lungs and lymph nodes, but also in the skin, eyes, and other organs.
Can ACE levels be elevated without sarcoidosis?
Yes. Other granulomatous conditions such as tuberculosis, as well as certain kidney or lung disorders, can raise ACE levels. The result must always be interpreted alongside other clinical findings.
Do ACE inhibitors affect the test result?
Yes, ACE inhibitor medications lower ACE levels in the blood and may produce a falsely low result. Inform your healthcare provider about all medications you are taking.
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Wellth Team

Wellth

Our content is written and reviewed by Wellth, and fact-checked against peer-reviewed research and current Swedish clinical guidelines.

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Medical Disclaimer

The information on this page is provided for informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. Wellth provides health information and testing services but is not a substitute for clinical care. Always consult a qualified healthcare provider if you have questions about a medical condition. If you are experiencing severe or urgent symptoms, contact your doctor or call 1177 Vårdguiden. Blood test results should be interpreted by a qualified healthcare professional in the context of your complete medical history.